Participant 3. University of La Laguna (ULL), Tenerife, Canary Islands, Spain

The University of La Laguna is located in Tenerife, the largest of the seven Canary Islands. Today the University of La Laguna has 25,000 students, 1,700 professors and 800 administrative and service employees. The university offers 56 official undergraduate and graduate degrees. The scientists from the ULL that will participate in the project are members of the University Institute of Bioorganic (IUBO) and the Department of Organic Chemistry and all of them belong to the Marine Chemistry Group at IUBO. This group was founded by Prof. Antonio González and Prof. Julio Delgado in the early 70's and is one of the pioneer groups in Europe in this field.

Role in the Project

• Large scale cultivation of different classes of dinoflagellates (WP1)
• Isolation and structural determination of pure bioactive compounds from complex mixtures including their stereochemistry and conformational properties. (WP2)
• Protein phosphatase inhibitory assays. (WP3)
• Drug discovery & development by NMR and computational methods (docking), including: target identification and/or validation; HTS by NMR; structure-activity relationships (SAR) by NMR (including epitope mapping, fragment based screening, elimination of false positives, confirming mechanism of action); thermodynamics of ligand-protein interactions for lead optimization (WP5)
• Biosynthesis of metabolites from dinoflagellates (WP4)

Dr. Manuel Norte Ph. D. Chemistry

Catedrático of Organic Chemistry.

Docent in Department of Organic Chemistry (Faculties of Pharmacy and Chemistry) and Research in Institute of Bioorganic.

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Expertise: Marine Natural Products; Marine Toxins; Biosynthesis

Dr. Jose Javier Fernandez Ph. D. Pharmacy

Profesor Titular of Organic Chemistry.

Docent in Department of Organic Chemistry (Faculties of Pharmacy and Chemistry) and Research in Institute of Bioorganic.

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Expertise: Bioorganic chemistry of marine natural product. Culture, isolation, structure elucidation, characterization by LC-MS and biosynthesis of toxic and bioactive metabolites from marine dinoflagellates; Biosynthesis

Dr. Maria Luisa Souto Suárez Ph. D. in Chemistry

Profesor Titular Contratado of Organic Chemistry

Docent in Department of Organic Chemistry (Faculty of Pharmacy and Technical College of Naval seamanship)

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Dr. Antonio Hernández Daranas Ph. D. Pharmacy.

Profesor Asociado Pharmaceutical Technology

Director of the pilot plant for the production of toxicological standarts

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Docent: Faculty of Pharmacy

Expertise: Structure, dynamics and thermodynamics of ligand-protein interactions by use of NMR, fluorescence and calorimetric techniques together with computational docking simulations. Isolation and structural characterization of marine natural products.