Participant 18. EBIOTEC S.A.,  Bergondo (La Coruña), Spain

[http://www.ebiotec.com] investigates the aging mechanisms associated with a dysfunction of the immune system and the role of dietary components and their interactions with other environmental factors in age-associated changes of the immune and inflammatory responses. Research looks to reverse and/or delay the onset of these immunologic and age-related changes by appropriate dietary modifications and to determine the molecular mechanisms by which antioxidant and prooxidant nutrients modulate immune cell functions. Methods have been developed to identify which food and environmental factors are responsible of immune dysfunction, and of particular and recent interest is the use of small and natural drugs derived from marine organisms to inhibit the effects of growth factors overproduced by different human tumor cell lines, which could be used as novel therapies for a wide range of solid tumors. EBIOTEC has expertise in both basic and applied research in Alzheimer’s disease and related dementias. Currently EBIOTEC investigates the molecular basis of molecular mechanisms involved in neurodegenerative processes and it is trying to develop new potential therapies by means of different molecular, biochemical, and immunological techniques to characterize these important pathological mechanisms. EBIOTEC has also a production plant, which is allowed to produce and sell dietary compounds for human consumption.

Role in the Project

• Collection and processing of marine organisms from Galician areas (WP1)
• In vitro screening (microglial cells, neuron cells, tumor cells) of crude marine organisms (WP3)
• Molecular studies of some of the mechanisms of action of new bioactive compounds such as apoptosis inducers, apoptosis inhibitors, modulation of cytokine production (WP3)

Prof. Ramón Cacabelos, M.D., Ph.D.

Professor of Physiology, Faculty of Medicine, Complutense University, Madrid, Spain

President of Euroespes S.A. and Director of Clinical Neuroscience Department at the Euroespes Biomedical Research Center, Euroespes, La Coruña, Spain.

President of IABRA (International Agency for Brain Research and Aging).

Email:   rcacabelos(at)euroespes.com, cibe(at)euroespes.com

Expertise: His research in biotechnology relates especially to the search and identification of bioactive compounds mainly from marine organisms

Dr. Valter Lombardi, Ph.D.

Euroespes Biotechnology, La Coruña, Spain

Email: biotecnologia(at)ebiotec.com

Expertise: In vitro screening and proteomic analysis of novel bioactive compounds.